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Traumatic Brain Injury (TBI)

  • Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
  • Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism
  • Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism
  • Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function 
  • Protective Effects of Cannabidiol Against Hippocampal Cell Death and Cognitive Impairment Induced by Bilateral Common Carotid Artery Occlusion in Mice
  • Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance
  • CBD reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke
  • Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
  • An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
  • Cannabinoid agonist rescues learning and memory after a traumatic brain injury
  • Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
  • Endocannabinoids and traumatic brain injury
  • Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist

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